Curriculum Vitae

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PERSONAL DATA

Name: LAURENCE ANTHONY COLE
Sex: Male
Date of Birth: February 8, 1953
Citizenship: U.S.A. and U.K.

Office Address: USA hCG Reference Service
P.O. Box 950, Angel Fire NM 87710

Tel: (575) 377-1330
e-mail: larry@hcglab.com

EDUCATION

B.M. 1971-1974, Medicine, Southampton University U.K. (not completed)
Ph.D., 1981, Biochemistry, Medical College of Wisconsin
2/81→10/83, University of Michigan, Ann Arbor, Michigan.
Postdoctoral Research Fellow, Department of Pharmacology

PROFESSIONAL APPOINTMENTS

10/83→3/85 University of Michigan, Ann Arbor, Michigan
Assistant Research Scientist in the Women’s Health Research and
Cancer Research Programs

3/85→5/92 Yale University, New Haven, Connecticut
Assistant Professor in Department of Obstetrics & Gynecology.

5/92→10/99 Yale University, New Haven, Connecticut. Associate Professor in Obstetrics & Gynecology, and in Yale Cancer Center

9/98→present Started CLIA-Certified USA hCG Reference Service, a cancer consulting service, Medical Director

11/99→3/2012 University of New Mexico, Albuquerque, New Mexico
Professor of Obstetrics & Gynecology and Biochemistry & Molecular Biology Chief, Division of Women’s Health Research

11/99→present Yale University, New Haven, Connecticut. Affiliate Professor in Obstetrics & Gynecology

08/05→3/2012 Became Privately Endowed Professor at University of New Mexico
“The Howard and Friedman Distinguished Professor of Obstetrics and Gynecology”

3/2012→present Consults on hCG and gestational trophoblastic diseases all over the world through the USA hCG Reference Service

PATENTS AND PATENTS PENDING

US patent (Yale) hCG free β-subunit in detecting the onset, progression and regression of cancer

US patent (Yale) hCG β-core fragment in detecting the onset, progression and regression of cancer

US patent (Yale) Gonadotropin β-subunit nicking enzyme, a marker of early stage malignancies

World patent (Yale) Prenatal screening for Down syndrome using hyperglycosylated gonadotropin

World patent (Yale) Prenatal screening for preeclamsia and pregnancy induced hypertension using hyperglycosylated gonadotropin

World patent (UNM) Hyperglycosylated hCG in treatment of gestational trophoblastic neoplasms

World patent (UNM) Invasive trophoblast antigen as a better pregnancy test,

World patent (UNM) Pregnancy tests and in-vitro fertilization pregnancy applications

World patent (UNM) Use of invasive trophoblast antigen (hyperglycosylated hCG) and progesterone in predicting outcome of pregnancies.

World patent (UNM) Hyperglycosylated hCG in predicting pregnancy failure

US Patent (UNM) A Point-of-care hyperglycosylated hCG test for pregnancy outcome

US patent (UNM) Use of hyperglycosylated hCG standards to calibrate hCG assay for optimal detection of pregnancy
World Patent (UNM) Hyperglycosylated hCG in Down syndrome screening

US Patent (UNM) Use of hyperglycosylated hCG in preventing pregnancy miscarriage

World Patent (UNM) Use of an antibody to hyperglycosylated hCG in curing placental and germ cell malignancies.

World Patent (UNM) Use of anti B152, anti-hyperglycosylated hCG in treating cancer

World Patent (UNM) Antibodies to hCG ß-subunit in the treatment or cure of all malignancies.

PRIZES AND AWARDS
October 95 Institute for Anticancer Research, Biannual Prize for best research
July 2000 American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry, Prize
April 2003 Gynecology Oncology, Outstanding Speaker Award 2003
November 2009 International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research

JOURNAL EDITORIAL BOARDS
1994-10/2001 Editor “Trophoblast Disease Update”

GRANTS

NIH CA44131
3/85 – 2/88 Yale. $740,000
2/88 – 1/93 Yale . $1,150,000
1/93 – 12/97 Yale. $1,200.000
2/98 – 1/03 Yale – UNM. $1,250,000

NIH HD36868
2/85 – 1/90 Yale, $920,000
1/90 – 6/95 Yale, $1,350,000
6/95 – 5/99 Yale, $870,000
5/99 – 4/04 UNM, $1,250,000

ACS
5/85-5/88 Yale ACS $200,000

DIAGNOSTIC PRODUCTS
3/04 – 2/06 UNM $240,000

QUEST
6/04 – 7/04 UNM $140,000

CHURCH AND DWIGHT

4/04 – 1/09 UNM $1,050,000

WADA/WHO

6/11 – 6/13 Funded, $200,000

PROFESSIONAL SOCIETIES
since 1992 Board, Intl. Society for the Study of Trophoblastic Neoplasms
since 2003 Associate Member, Society of Gynecologic Oncologists
since 1983 Member of the Endocrine Society
since 1993 Member of the American Association for Clinical Chemistry

CHAIRING CONFERENCES
2001 11th Word Congress on Gestational Trophoblastic Diseases, Santa Fe
2008 2nd International Congress on Gonadotropins and Receptors, London UK

TEACHING
1985-1999 Yale University Medical School, Biochemistry, LH-FSH, Hormones of pregnancy.

1985-1999 Yale University, Undergraduate, Reproductive Biology

1985-1999 Yale University, Undergraduate, Biochemistry

1999-2011 University New Mexico, Medical School, Introduction to Obstetrics and Gynecology, Menstrual Cycle, Puberty, Reproductive Disorders.

2000-2012 Graduate Strudents, Biochemistry, Biochemistry of Endocrinology, 3 credits, course director

2000-2011 Graduate Student Biochemistry, Biochemistry of Disease, 3 credits (Cancer Biology section, Gestational Trophoblastic Disease section

1999-2012 Medical student rotating through Obstetrics and Gynecology, 2 lectures, hCG, LH and FSH, presented 8 times each year

1999-2011 Medical Students, Reproductive Biology Course, 5 lectures each year

1999-2011 Undergraduate, Human Reproduction, 3 credit course, course director

BIBLIOGRAPHY

1. BOOKS
2003, Gestational trophoblastic disease, eds. Hancock BW, Newlands ES, Berkowitz RS, Cole LA. Chapman and Hall, London, 400 pages, first edition.
2007, Gestational trophoblastic disease, eds. Hancock BW, Berkowitz RS, Cole LA. Chapman and Hall, London, 450 pages, second edition
2010, Human Chorionic Gonadotropin (hCG), ed. Cole LA, Elsevier, 382 pages. 
2012, The Smiles of World, ed. Cole LA. Authorhouse Publishers, 165 pages.
2012, Larry’s Left Side, Cole LA. Arrow Publications, 200 pages.
2013, The Great Southwest, ed. Cole LA, Authorhouse Publishers, Bloomington IN, 250 pages.
2013, Human Chorionic Gonadotropin (hCG), ed. Cole LA, Elsevier, Oxford UK, 433 pages, second edition.
2013 The Biology and Medical Dynamic of Human Reproduction, Nova Scientific Publishers, 285 pages.
2014 The Glycopeptins, Nova Scientific Publishers, 180 pages.
2014 The Science of Gestational Trophoblastic Diseases, Nova Scientific Publishers, 188 pages.
2014 Human-ology, Elsevier-Academic Press, 630 pages

2. PEER REVIEWED MEDICAL JOURNALS
1. Cole, L.A., Hussa, R.O., and Rao, C.V. Discordant synthesis and secretion of human chorionic gonadotropin and subunits by cervical cancer cells. Cancer Res. 41:1615-1619, 1981.
2. Cole, L.A., and Hussa, R.O. Use of glycosidase digested human chorionic gonadotropin ß-subunit to explain the partial binding of glycoprotein hormones to Con A. Endocrinology, 109:2276-2279, 1981.
3. Story, M.T., Cole, L.A., and Hussa, R.O. A procedure using immobilized antibody for the isolation of the ß-subunit of human chorionic gonadotropin from the culture fluids of a ß-subunit-secreting nontrophoblastic cell line. J.Clin.Endocrinol.Metab. 53:1090-1095, 1981.
4. Cole, L.A., Birken, S., Sutphen, S., Hussa, R.O., and Pattillo, R.A. Absence of the COOH-terminal peptide on ectopic human chorionic gonadotropin ß-subunit (HCG-ß). Endocrinology 110:2198-2200, 1982.
5. Cole, L.A., Hartle, R.J., Laferla, J.J., and Ruddon, R.W. Detection of the free ß subunit of human chorionic gonadotropin in cultures of normal and malignant trophoblast cells, pregnancy sera, and sera of patients with choriocarcinoma. Endocrinology 113:1176-1178, 1983.
6. Pattillo, R.A., Hussa, R.O., Cole, L.A., and Yorde, D.E. Hormone synthesis by normal and neoplastic trophoblast. In: Biology of Trophoblast (eds: Loke and Whyte), Elsevier Science, pp. 283-316, 1983.
7. Cole, L.A., Kroll, T.G., Ruddon, R.W., and Hussa, R.O. Differential occurrence of free ß and free alpha subunits of human chorionic gonadotropin (hCG). J.Clin.Endocrinol.Metab. 58:1200-1202, 1984.
8. Cole, L.A., and Hussa, R.O. The carbohydrate on human chorionic gonadotropin produced by cancer cells. Adv.Exper.Med.Biol.176:245-270,1984.
9. Cole, L.A., Perini, F., Birken, S., and Ruddon, R.W. An oligosaccharide of the O-linked type distinguishes the free from the combined form of hCG alpha-subunit. Biochem.Biophys.Res.Comm. 122:1260-1267, 1984.
10. Hussa, R.O., and Cole, L.A. New horizons in clinical hCG detection. Adv.Exper.Med.Biol. 176:217-244, 1984.
11. Nagelburg, S.B., Cole, L.A., and Rosen, S.W. A novel form of the free ß-subunit of chorionic gonadotropin in the serum of a woman with epidermoid carcinoma. J.Endocrinol. 107:403-408, 1985.
12. Cole, L.A., Birken, S., and Perini, F. The structures of the serine-linked sugar chains on human chorionic gonadotropin. Biochem.Biophys.Res.Comm. 126:333-339, 1985.
13. Cole, L.A., Scheid, J.M., and Tannen, R.L. Induction of mitochondrial metabolism and pH-modulated ammoniagenesis in LLC-PK1 cells. Am.J.Physiol., 251 (Cell Physiology 20) C293-C298, 1986
14. Castor, C.W., Cabral, A.R., Cole, L.A., Walz, D.A., Hossler, P.A., Bignall, M.C., Furlong, M.A., and Smith, E.M. Regulation of synovial cell metabolism by growth factors. Rheumatology-85 (eds. Brooks and York), Elsevier pp. 73-76, 1986.
15. Hussa, R.O., Fein, H.G., Pattillo, R.A., Nagelberg, S.B., Rosen, S.W., Weintraub, B.D., Perini, F., Ruddon, R.W., and Cole, L.A. A distinctive form of human chorionic gonadotropin ß-subunit -like material produced by cervical carcinoma cells. Cancer Res. 46, 1948-1954, 1986.
16. Cole, L.A., Restrepo-Candelo, H., Lavy, G., and DeCherney, A. hCG free ß-subunit an early marker of outcome of in vitro fertilization clinical pregnancies. J.Clin.Endocrinol.Metab., 64:1328-1330, 1987.
17. Cole, L.A. O-Glycosylation of proteins in the normal and neoplastic trophoblast. Troph.Res., 2:139-148, 1987.
18. Grotjan, H., and Cole, L.A. Ovine and human luteinizing hormone deglygosylated with endoglycosidase F. Ann. N.Y.Acad.Sci. 513:329-31, 1987.
19. Imamura, S., Armstrong, G.A., Birken, S., Cole, L.A., and Canfield, R.E. Highly specific and sensitive measurements of desialylated forms of human chorionic gonadotropin with lectin immunoradiometric assays. Clin.Chimica Acta, 163:339-349, 1987.
20. Cole, L.A. Distribution of O-linked sugar units on hCG and its free alpha-subunit. Mol.Cellular Endocrinol., 50:45-57, 1987.
21. Cole, L.A., Metsch, L. and Grotjan, H.E. Significant steroidogenic activity of luteinizing hormone is maintained after enzymatic removal of oligosaccharides. Molec.Endocrinol., 1:621-627, 1987.
22. Cole, L.A. The O-linked oligosaccharides are strikingly different on pregnancy and choriocarcinoma hCG. J.Clin.Endocrinol.Metab., 65:811-813, 1987
23. Cabral, A.R., Cole,L.A., Walz, D.A., and Castor, C.W. Connective tissue activation. XXXII. Structural and biologic characteristics of mesenchymal cell-derived connective tissue activating peptide-V. Arthritis Rheum., 30:1393-400, 1987
24. Restrepo-Candelo, H., Lavy, G., Thatcher, S.S., DeCherney, A.H., and Cole, L.A. Free ß-subunit of human chorionic gonadotropin measurements in in vitro fertilization pregnancies. prediction of outcome, Rev. Latinoamer. Steril. Fertil. 1:142-146, 1987
25. Birken, S., Agosto, G., Amr, S., Nisula, B., Cole, L., Lewis, J., and Canfield, R.E. Characterization of antisera distinguishing carbohydrate structures in the ß carboxyl-terminal region of human chorionic gonadotropin. Endocrinology, 122:2054-2063, 1988
26. Cole, L.A., Wong, Y., Latif, M., Chambers, J.T., Chambers, S.K. and Schwartz, P.E. Urinary human chorionic gonadotropin free ß-subunit and ß-fragment: new markers of gynecologic cancers. Cancer Res., 48:1356-1360, 1988
27. Birken, S., Armstrong, E.G., Kolks, M.A.G., Cole, L.A., Agosto, G.M., Krichevsky, A., and Canfield, R.E. The structure of the human chorionic gonadotropin ß-subunit core fragment from pregnancy urine. Endocrinology, 123:572-583, 1988
28. Cole, L.A. Occurrence and properties of glycoprotein hormone free subunits. In: Microheterogeneity of Glycoprotein Hormones (eds. Grotjan and Keel), CRC,pp. 53-74, 1988.
29. Cole, L.A. Hormones and Reproduction, Yale-New Haven Teachers Institute, Volume 5, pp 1-168, 1988
30. Grotjan, H.E., and Cole, L.A. hCG microheterogeneity. In: Microheterogeneity of Glycoprotein Hormones (eds. Grotjan and Keel), CRC, pp. 219-237, 1988.
31. Cole, L.A., Schwartz, P.E., and Wong, Y. Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system: I. Sensitivity and specificity, comparison with other markers. Gyn.Onc., 31:82-90, 1988
32. Wong, Y., Schwartz, P.E., Chambers J.T., and Cole, L.A. Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system: II. Initial serial studies. Gyn.Onc., 31:91-100, 1988
33. Cole, L.A., and Birken, S. Origin and Occurrence of human chorionic gonadotropin ß-subunit core fragment. Molec.Endocri., 2:825-830, 1988
34. Cole, L.A., and Wang, Y. Use of intact human chorionic gonadotropin and its free alpha- and ß-subunit in the detection and management of gynecologic cancers. Ch. J. Medicine., 68:101-103, 1988.
35. Sahai, A., Cole, L.A., Clarke, D.L., and Tannen, R.L. Rocking promotes cellular differentiated properties in cultured cells by improved oxygenation. Am.J.Physiol., 256:C1064-C1069, 1989
36. Cole, L.A., and Nam, J.H. Urinary gonadotropin fragment measurements in the diagnosis and management of ovarian cancer. Yale J. Med. Bio., 62:367-378, 1989.
37. Sahai, A., Cole, L. A., and Tannen, R.L. Pathways of regulation of metabolism by LLC-PK1 cells in culture. J.Lab.Clin.Med., 114:285-293, 1989
38. Nam, J.H., Cole, L.A., Chambers, J.T., and Schwartz, P.E. Urinary gonadotropin fragment, a new tumor marker: I. Assay development and cancer-specificity. Gynecol. Oncol., 36:383-390, 1990
39. Cole, L.A., Nam, J.H., Chang, K.C., Chambers, J.T., and Schwartz, P.E. Urinary gonadotropin fragment, a new tumor marker: II. For differentiating a benign from a malignant pelvic mass. Gynecol. Oncol., 36:391-394, 1990
40. Nam, J.H., Chang, K.C., Chambers, J.T., Schwartz, P.E., and Cole, L.A. Urinary gonadotropin fragment, a new tumor marker: III. Use in cervical and vulvar cancers. Gynecol. Oncol., 38:66-70, 1990
41. Cole, L.A., Kardana, A., and Birken, S. The isomers, subunits and fragments of hCG. Serono Symposia, 65:59-80, 1990
42. McGill J., Cole, L.A. Nam, J., Thornson, A., Christensen, M., Mailliard, J., Chun, M., Wilwerding, M., Nam, J., and Boman, B. Urinary gonadotropin fragment (UGF): A potential “marker” of colorectal cancer, J. Tumor Marker Oncol. 5:175-177, 1990
43. Cole L.A. Human chorionic gonadotropin production in early and 6-40 week pregnancies, and in women with choriocarcinoma. J. Cancer Res. Clin. Onc. 116:1127, 1990.
44. Nam, J.H., Chambers, J.T., Schwartz, P.E., and Cole, L.A. Urinary gonadotropin fragment, a new tumor marker: IV. Use in endometrial and uterine cancers. Gynecol. Oncol. 39:353-357, 1990.
45. Kardana, A., and Cole, L. A. Serum hCG ß-core fragment is masked by associated macromolecules. J. Clin. Endocri. Metab. 71:1393-1395, 1990
46. Castor, C.W., Waltz, D.A., Johnson, P.H., Hossler, P.A., Smith, E.M., Bignall, M.C., Aaron, B.P., Underhill, P., Lazar, J.M., Hudson, D.H., Cole, L.A., Perini, F., and Mountjoy, K. Connective tissue activation XXXIV: effects of proteolytic processing on the biologic activities of CTAP-III. J. Lab. Clin. Med. 116:516-526, 1990.
47. Knight G.J., and Cole, L.A., Free ß-subunit hCG measurements: An alternative to hCG for fetal Down Syndrome screening? Clin. Chem. 37:779-782, 1991.
48. Cole L.A., Kardana, A., Andrade-Gordon, P., Gawinowicz, M.A., Morris, J.C., Bergert, E.R., O’Connor, J., and Birken, S. The Heterogeneity of hCG: III. The occurrence, biological and immunological activities of nicked hCG. Endocrinology 129:1559-1567, 1991.
49. Kardana, A., Elliott, M.E., Gawinowicz, M.A., Birken, S., and Cole, L.A. The
heterogeneity of hCG: I. Characterization of peptide variations in 13 individual preparations of hCG. Endocrinology 129:1541-1550, 1991.
50. Birken, S., Gawinowicz, M.A., Kardana, A., and Cole, L.A. The Heterogeneity of hCG: II. Characteristics and origins of nicks in hCG reference standards. Endocrinology 129:1551-1558, 1991.
51. Kardana, A., and Cole, L.A. Polypeptide Nicks Cause Erroneous Results in Human Chorionic Gonadotropin Free ß-subunit Assays. Clin. Chem., 38:26-33,1992
52. Rotmensch, S., Liberati, M., Kardana, A., Copel, J.A., Ben-Rafael, Z., Cole, L.A. (1996). Nicked free β-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening. Am J Obstet Gynecol 174, 609-611.
53. Cole, L.A., and Kardana, A. Discordant Results in human chorionic gonadotropin assays. Clin. Chem., 38:263-270, 1992
54. Schwartz, P.E., Chambers, J.T., Pellerito, J., Hammers, L., Cole, L.A., Yang-Feng, T., Smith, P., Mayne, S., and Makuch, R. Early detection of ovarian cancer: Background,rationale and structure of the Yale early detection program. Yale J. Biol. Med., 64:557-571, 1991.
55. Cole, L.A., and Kardana, A. The biological and clinical significance of nicks in human chorionic gonadotropin and its free ß-subunit. Yale J. Bio. Med., 64:627-627, 1991.
56. Schwartz, P.E., Chambers, J.T., Taylor, K., Pellerito, J., Hammers, L., Cole, L.A., Yang-Feng, T., Smith, P., Mayne, S., and Makuch, R. Early detection of ovarian cancer: Preliminary results of the Yale Early Detection Program. Yale J. Biol. Med., 64:573-582, 1991.
57. D’Agostino, R.S., Cole, L.A., Ponn, R.B., Stern, H., Schwartz, P.E. Urinary gonadotropin fragment in patients with lung and esophageal disease. J. Surg. Oncol. 49:147-150, 1992.
58. Merz, W.E., Cole, L.A. Formation of a hCG variant with truncated peptide moiety as a biosynthetic product in vitro. Troph. Res., 7: 1993
59. Cole, L.A., Kardana, A., Park S-Y., Braunstein, G. The deactivation of hCG by nicking and dissociation. J. Clin. Endocrinol. Metab., 76:704-710, 1993
60. Cole, L.A., Seifer, D.B., Kardana, A., Braunstein, G.D. Selecting human chorionic gonadotropin immunoassays: Consideration of crossreacting molecules in first trimester pregnancy serum and urine. Am. J. Obstet. Gynecol., 168:1580-1586, 1993
61. Bohler, H., and Cole, L.A. Human chorionic gonadotropin in pregnancy serum and urine. Assisted Reprod. Rev., 3:48-48, 1993
62. Schwartz, P.E., Chambers, J.T., Cole, L.A., and Makuch, R. Urinary gonadotropin fragments. Anticancer Res., 13:1722-1725, 1993
63. Cole, L.A., Kohorn, E.I., Kim, G.S. Detecting and monitoring trophoblast disease: New perspectives in measuring human chorionic gonadotropin levels. J Reprod. Med. 39:193-200, 1994.
64. Cole, L.A., Nam, J-H., Park, S-Y., Koh, M.W., Tanaka, A. Urinary Beta Core Fragment: 7 years later. J. Tumor Marker Onc., 9:53, 1994
65. Yoshimura, M., Pekary, A.E., Pang, X-P., Berg, L., Cole, L.A., Kardana, A., and Hershman, J.M. Effect of peptide nicking in the human chorionic gonadotropin beta-subunit on stimulation of recombinant human TSH receptors. Eur. J. Endocrinology, 130:92-96, 1994.
66. Cole, L.A., Kardana, A., Seifer, D.B., and Bohler, H.C. Urine hCG β-subunit core fragment, a sensitive test for ectopic pregnancy. J. Clin. Endocrinol. Metab., 78:497-499, 1994.
67. Kardana, A., Cole, L.A. Human chorionic gonadotropin β-subunit nicking enzymes in pregnancy and cancer patient serum. J. Clin. Endocrinol. Metab.,79:761-767, 1994
68. Cole, L.A. β-core fragment (β-core, UGP or UGF). Tumor Marker Update. 6:69-75, 1994.
69. Cole, L.A. Human chorionic gonadotropin and related molecules. Diagn. Endocrinol. Metab., 12:207-224, 1994.
70. Tanaka, A., and Cole, L.A. Improved methods for detecting beta-core in normal and cancer patient urines. Clin. Chem., 40:2317-2318, 1994.
71. Hoermann, R., Berger, P, Spoettl, G., Gillesberger, F., Kardana, A., Cole, L., and Mann, K. Immunological recognition and clinical significance of nicked human chorionic gonadotropin in testicular cancer. Clin. Chem., 40:2306-2312, 1994.
72. Cole, L.A. Multiple hCG-related molecules. In: Screening for Down’s Syndrome (Grudzinskas J., Chard, T., Chapman, M., and Cuckle, H., eds.), Cambridge Univ. Press, Cambridge, pp 119-140, 1994.
73. Goodwin, T.M., Hershman, J.M., and Cole, L.A. Increased concentration of the free β-subunit of human chorionic gonadotropin in hyperemesis gravidarum. Acta Obstet. Gynecol. Scand. 73:770-772, 1994.
74. Fu, C.Y., Cole, L.A. and Kardana, A. Urinary gonadotropin fragment measurement in the monitoring of trophoblastic disease. Chung-Hua Fu Chan Ko Tsa Chih [Chinese Journal of Obstetrics & Gynecology]. 29(8):475-7, 510-511, 1994.
75. Cole, L.A. hCG, nicked hCG, free subunits and fragments in pregnancy, trophoblast disease and cancer. Clin. Chem. 41:26-27, 1995.
76. Cole, L.A., Down’s syndrome screening using urine β-core fragment test; Choice of immunoassay. Prenatal Diagnosis, 25:679-682, 1995.
77. Rotmensch, S., Liberati, M., Kardana, A., Mahoney, M., Hobbins, J.C., and Cole, L.A. Assay of nicked hCG ß-subunit in down syndrome pregnancies. Am. J. Obstet. Gynecol., 174:609-611, 1996.
78. Kardana, A., Braunstein, G.D., and Cole, L.A., Gonadotropin β-subunit nicking enzyme (GBNE), a potential test for detecting early malignancies. Oncology Res., 8:13-16, 1996.
79. Cole, L.A., Tanaka, A., Kim, G.S., Park, S-Y., Koh, M.W., Schwartz, P.E., Chambers, J.T., and Nam, J-H. Beta core fragment (β-core / UGF / UGP), a tumor marker: Seven year report. Gynecol. Oncol., 60:264-270, 1996.
80. Cole, L.A. Multiple hCG-related molecules in pregnancy and trophoblast disease serum and urine samples. In: “Clinical ligand assay society syllabus”, ed. C. D. Hawker, C.L.A.S., Los Angeles, pp 91-99, 1996.
81. Cole, L.A., Isozaki, T., Palomaki, G., Canick, J., Kellner, L., Saller., D., and Cuckle, H. Detection of β-core fragment in second trimester Down’s syndrome pregnancies. Early Human Dev., 47:S47-48, 1996.
82. Schwartz, P.E., Cracchiolo, B.M., Cole, L.A. Clinical application of urinary gonadotropin peptides (UGP) in gynecologic oncology. Anticancer Res., 16:2135-2140, 1996.
83. Cole, L.A. β-core fragment. In: Tumor Markers, Ed. Newlands, E.S., Leeds Univ. Press, Leeds, U.K., 1997.
84. Cole, L.A. Stability of hCG free β-subunit and β-core fragment in urine. Prenat. Diagn., 17:185-189, 1997.
85. Tanaka, A., and Cole, L.A. Comparison of 4 kits for measuring β-core fragment. Jap J Clin Chem 17: 735-738, 1997.
86. Cole, L.A. β-core fragment in Down syndrome pregnancies. Screen News, 4:9-10, 1997.
87. Isozaki, T., Palomaki, G.E., Bahado-Singh, R.O., Cole, L.A. Screening for Down syndrome pregnancy using β-core fragment: prospective study. Prenat. Diagn. 17:407-413, 1997.
88. Cole, L.A., Leonard H. Kellner, L.H., Isozaki, T., Palomaki, G.E., Iles, R.K., Walker, R., Ozaki, M., and Canick, J. Comparison of 12 assays for detecting hCG and related molecules in urine samples from Down syndrome pregnancies. Pren. Diagn., 17:607-614, 1997.
89. Elliott, M.M., Kardana, A. and Cole, L.A. Carbohydrate and Peptide structure of the α- and β-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine 7:15-32, 1997.
90. Cole, L.A., Jacobs, M., Isozaki, T., Palomaki, G.E., Bahado-Singh, R.O., Mahoney, M.J. Screening for Down syndrome using urine hCG free β-subunit in the second trimester of pregnancy. Pren. Diagn. 17, 1107-1111, 1997.
91. Cole, L.A., Acuna, E., Isozaki, T., Palomaki, G.E., Bahado-Singh, R.O., Mahoney, M.O. Combining β-core fragment and total estriol measurements to test for Down syndrome pregnancies. Pren. Diagn. 17, 1125-1133, 1997.
92. Cole, L.A. Immunoassay of hCG, its Free Subunits and Metabolites. Clin. Chem., 43: 2233-2243, 1997.
93. Cole, L.A. hCG, its Free Subunits and Metabolites in Pregnancy and
Trophoblastic Disease. J. Reprod. Med., 43: 3-10, 1998.
94. Cole, L.A., Cermik D., Bahado-Singh, R. Oligosaccharide variants of hCG-related molecules: Potential screening markers for Down syndrome. Prenat. Diagn. 17:1188-1190, 1997.
95. Cole, L.A. Human chorionic gonadotropin (hCG), free α (free α), free β (free β) and β-core fragment (β-core). Diagn. Endocrinol. Metab., 15:199-220, 1997.
96. Cole, L.A. Human chorionic gonadotropin assay. In: Gestational trophoblastic disease, eds. Hancock B.W., Newlands E.S., and Berkowitz, R.S. Chapman and Hall, London, pp 77-94, 1997.
97. Kardana A., and Cole, L.A. The stability of hCG and free β-subunit in serum samples. Pren Diagn 17:141-147, 1997.
98. Cole, L.A., Isozaki, T., Jones, E.E. Urine β-core fragment, a potential screening test for ectopic pregnancy and spontaneous abortion. Fetal Diagn. Ther. 12:336-339, 1997.
Bahado-Singh, R.O., Oz, U.A., Acuna, E., Cermik, D., Mahoney, M.J., and Cole, L.A. A new screening protocol combining urine β-core fragment and ultrasound for Down syndrome detection. Am J Obstet Gynecol 178:779-792, 1998.
Bahado-Singh, R.O., Oz, U.A., Kovanci, E., Cermik, D., Flores, D., Copel J., Mahoney, M.J., and Cole, L.A. New triple screen test for Down syndrome: Combined urine analyted and serum AFP. J. Maternal Fetal Med., 7:111-114, 1998.
101. Lee, I-S., Chung, D.Y.K., Cole, L.A., Copel, J.A., Isozaki, T., Hsu, C-D. Elevated serum nicked hCG in preeclamptic pregnancies. Obstet. Gynecol. 90:889-892, 1997.
102. Bahado-Singh, R.O., Oz, U., Isozaki, T., Seli, E., Kovanci, E., Hsu, C-D., and Cole, L.A. Mid-trimester urine β-subunit core fragment levels and the subsequent development of preeclampsia. Am. J. Ob. Gyn., 179:738-741, 1998.
Cole, L.A., Omrani, A., Cermik, D., Bahado-Singh, R.O., and Mahoney, R.O. Hyperglycosylated hCG, a potential alternative to hCG in down syndrome screening. Prenat. Diagn., 18:926-933, 1998.
Cole, L.A. Prenatal screening for Down syndrome using hyperglycosylated gonadotropin. PCT Comm., WO98/10282, 1-22, 1998.
Cole, L.A., Shahabi, S., Rinne, K.M., Bahado-Singh, R.O., Mahoney, M.J. Hyperglycosylated hCG. Down Syndr. News 5:6-7,1998.
Cole, L.A., Abbott, T.J., Armstrong, G.E. The Nature and Specificity of Bayer Corporation and Chiron Diagnostics hCG Immunoassays. Clin. Chem., 44:2001-2002, 1998
Cole, L.A. Early detection of ectopic pregnancy. PCT Comm., WO98/23300, 1-14, 1998.
108. Bahado-Singh, R.O., Oz, U., Flores,D, Cermik, D., Acuna, E., Mahoney, M.J., and Cole, L.A. Nuchal thickness, urine β-core fragment and age for Down syndrome pregnancy. Am. J. Ob. Gyn. 180: 491-495, 1999.
109. Canick, J.A., Kellner, L.H., Cole, L.A., Cuckle, H.S. Urinary analyte screening: A noninvasive detection method for Down syndrome? Molec. Med. Today, 5:68-73, 1999.
110. Cole, L.A. Production, structure, clinical detection and monitoring of hCG in trophoblast disease. Intl. J. Gynecol. Obstet. 60: S131-S132, 1998.
Nam, J-H, Kim, J-K, Park, S-Y, Walker, R., and Cole, L.A. Urinary gonadotropin fragment (UGF) measurements, its efficacy in patients with gynecologic and various malignancies. J. Korean Cancer Assoc. 30: 561-572, 1998.
112. Butler, S.A., Cole, L.A., Chard, T., and Iles, R.K. Dissociation of hCG into its free subunits is dependent on naturally occurring molecular structural variation, sample matrix and storage conditions. Ann Clin Biochem, 35:754-760, 1998.
113. Cole, L.A. Rinne, K.M., Mahajan, S.M., Oz, U.A., Shahabi, S., Mahoney, M.J., Bahado-Singh, R.O. Urinary Screening Tests for Fetal Down Syndrome: I. Fresh ß-Core Fragment. Prenat Diagn, 19:340-350, 1999.
114. Cole, L.A. Shahabi, S., Rinne, K.M., Oz, U.A., Bahado-Singh, R.O., Mahoney, M.J. Urinary Screening Tests for Fetal Down Syndrome: II. Hyperglycosylated hCG. Prenat Diagn, 19:351-359, 1999.
Cole L.A., Phantom hCG and phantom choriocarcinoma. Gynecol Oncol, 71:325 329, 1998
Shahabi, S., Rinne, Oz, U.A., Bahado-Singh, R.O., Mahoney, M.J., Omrani, A., Baugarten, A., and Cole, L.A. Serum hyperglycosylated hCG a potential screening test for fetal Down syndrome. Prenat Diagn, 19:488-489, 1999.
Cole, L.A., Rinne, K.M., Shahabi, S., and Omrani, A. False positive hCG levels leading to unnecessary surgery and chemotherapy, and needless occurrences of diabetes and coma. Clin Chem, 45:313-314, 1999.
118. Cole, L.A., Shahabi, S., Bahado-Singh, R. Hyperglycosylated hCG review. Down Syndr News 6:10-11, 1999.
119 Rinne, K, Shahabi, S., and Cole, L.A. Following metastatic placental site trophoblastic tumor with urine β-core fragment. Gynecol Oncol, 74:302-303, 1999.
120. Birken, S., Krichevsky, A., O’Connor, J., Schlatterer, J., Cole, L.A., Kardana, A., and Canfield, R. Development and characterization of antibodies to a nicked and hyperglycosylated form of hCG from a choriocarcinoma patient. Endocrine J., 10: 137-144, 1999.
121. Cuckle, H.S., Shahabi, S., Sehmi, I., Jones, R., and Cole, L.A. Maternal urine hyperglycosylated hCG in pregnancies with Down’s Syndrome. Prenat Diagn, 19: 918-920, 1999.
122. Cole, L.A., Shahabi, S., Oz, U.A., Bahado-Singh, R.O., and Mahoney, M.J. Hyperglycosylated hCG (Invasive Trophoblast Antigen) Immunoassay: a New Basis for Gestational Down Syndrome Screening. Clin. Chem. 45:2109-2119, 1999
Bahado-Singh, R., Kovanci, E., Cermik, D., Mahoney, M.J., and Cole, L.A. A high sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness and age. Am J Obstet Gynecol 180:169-173, 1999.
Rotmensch, S., and Cole, L.A. False diagnosis and needless therapy of presumed malignant disease in women with false-positive human chorionic gonadotropin concentrations. The Lancet 355:712-715, 2000.
Bahado-Singh, R, Shahabi, S., Mahoney, M.J., and Cole, L.A. Urine hyperglycosylated hCG plus ultrasound biometry for detection of Down syndrome in the second trimester in a high-risk population. Obstet Gynecol 95:889-894, 2000.
Weinans JN, Butler SA, Mantingh A, Cole LA. Urinary hyperglycosylated hCG in first-trimester screening for chromosomal abnormalities. Prenat Diagn., 20:976-978, 2000
127. Kohorn, E.I., Cole, L.A. Nicked human chorionic gonadotropin in trophoblastic disease. Intl. J. Obstet Gynecol., 10:330-335, 2000.
128. Cole, L.A. Dosaggio immunometrico della gonadotropina corionica umana, delle sue subinita libere e dei suoi metaboliti. Lig Assay 5:70-81, 2000.
129. Bahado-Singh, R., Oz, U., Flores, D., Hsu, C., Mari, G., and Cole, L.A. Maternal urine ß-core fragment level and small for gestational age neonates. Obstetrics and Gynecology, 95:662-666, 2000.
130. Cole L.A. Khanlian S., Butler, S. False-positive hCG immunoreactivity. Lab Medica 18:9-10, 2001.
131. Cole, L.A., Shahabi, S., Butler, S., Mitchell, H., Newlands, E.S., Behrman, H.R., Verrill, H.L. Utility of commonly used commercial hCG immunoassays in the diagnosis and management of trophoblastic diseases. Clin Chem 47:308-315, 2001.
132. Cole, L.A., Butler, S.A. False positive or phantom hCG result: a serious problem.
Clin Lab Intl 25:9-14, 2001.
133. Butler S.A., Cole, L.A. The Use of Heterophilic Antibody Blocking Agent (HBT) in Reducing False Positive hCG Results. Clin Chem 47:1332-1333, 2001
134. Butler S.A., Cole, L.A., Detection of early pregnancy forms of hCG by Home Pregnancy Test Devices, Clin Chem 2001 47: 2131-2136.
135. Meyer T. Cole LA. Richman PI. Mitchell HD. Myers J. Rustin GJ. High levels of hCG in choriocarcinoma can result in renal failure and a false-negative pregnancy test in men. Clin Oncol 13:301-303, 2001.
136. Feister HA. Auerbach BJ. Cole LA. Krause BR. Karathanasis SK. Identification of an IL-6 response element in the human LCAT promoter. Journal of Lipid Research. 43(6):960-70, 2002.
137. Cole LA. Use of hCG Tests for Evaluating Trophoblastic Diseases: Choosing an Appropriate hCG Assay, False Detection of hCG, Unexplained Elevated hCG, and Quiescent Trophoblastic Disease. In: Gestational Trophoblastic Disease, 2nd Edition (Eds: Hancock BW, Newland ES, Berkowitz RS, Cole LA), Chapman and Hall, London, pp 130-142, 2002.
138. Bahado-Singh R.O., Oz, A.U., Kingston, J.M., Shahabi, S., Hsu, C.D., and Cole, L.A. The role of hyperglycosylated hCG in trophoblast invasion and the prediction of subsequent pre-eclampsia. Prenat Dagn 22:478-481, 2002.
139. Butler S.A., Cole, L.A. Falsely elevated hCG leading to unnecessary therapy Obstet Gynecol, 99:515-516, 2002.
140. Cole, L.A. and Butler S.A., hCG, its Free Subunits and Metabolites in Trophoblastic Diseases. J. Reprod. Med. 47:433-444, 2003.
141. Bahado-Singh RO, Shahabi S, Karaca M, Mahoney MJ, Cole LA, Oz UA. The comprehensive midtrimester test: high-sensitivity Down syndrome test. Am J Obstet Gynecol 186:803-808, 2003.
142. Cole LA. ITA a powerful serum and urine screening method in maternal Down syndrome detection: Update 2003, Down Syndr News 9:25, 2002
143. Smith HO, Hilgers RJ, Qualls CR, Bedrick EJ, Prairie BA, Rayburn WF, Waxman AG, Stephens ND, Padilla LA, Cole, LA, Swanson M, Wiggins CL, Key CR, Ethnic trends in gestational trophoblastic disease in New Mexico, and trends in choriocarcinoma. Trophobl Dis Upd, 4:9-12, 2003
144. Cole LA, Hyperglycosylated hCG cannot be measured using a sialic acid-specific lectin immunoassay. Prenat Diagn 23: 176-178, 2003.
145. Khanlian SA, Smith HO, Cole LA. Persistent Low Levels of hCG: A Pre-malignant gestational trophoblastic disease. Am J Obstet Gynecol, 188: 1254-1259, 2003.
146. Cole, LA, Sutton JM. hCG Tests in the Management of Gestational Trophoblastic Diseases. Clin Obstet Gynecol, 46:533-540, 2003
147. Smith HO, Hilgers RD, Bedrick EJ, Qualls CR, Wiggins CL, Rayburn WF, Waxman AG, Stephens ND, Cole L, Swanson M, Key CR. Ethnic differences in risk for gestational trophoblastic disease in New Mexico: A 25-year population-based study. Am J Obstet Gynecol 2003; 188:357-66.
148. Davies, S., Byrn, F., Cole, L.A. Testing for Early Pregnancy Viability. Clinics Lab Med., 23:257-264, 2003.
149. Cole LA. Problems with interpretation of hCG results in gestational trophoblastic diseases. Jap J Obstet Gynecol 2003; 20:11-14.
150. Cole LA, hCG and Pregnancy Test. In: Diagnostic Tests for Pregnancy (ed. A. Gronowski), Saunders, 2003.
151. Cole LA. Gestational Trophoblastic Disease, eds. Hancock BW, Newlands ES, Berkowitz RS and Cole LA. Sheffield University Press, 394 , 2003
152. Cole LA, Khanlian SA, Sutton JM, Davies S, Stephens N. Hyperglycosylated hCG (Invasive Trophoblast Antigen, ITA) a Key Antigen for Early Pregnancy Detection. Clin Biochem, 2003;36;647-655
153. Cole LA, Sutton JM, Stephens ND. Invasive trophoblast antigen (ITA): A new high-sensitivity test for detecting gestational Down syndrome J Clin Ligand Assay, 26: 23-28, 2003.
154. Sutton JM, Khanlian SA, Cole LA, Butler SA. hCG Urinary Metabolites in Breast Milk. Hormone Metab Res 2004; 36:75-78.
155. Cole LA, Khanlian SA, Sutton JM, Davies S, Rayburn WF. Accuracy of home pregnancy tests at the time of missed menses. Am J Obstet Gynecol, 2004;190:100-105.
156. Sutton JM, Cole LA. Sialic acid deficient ITA: A new future in Down syndrome screening. Down Syndr News 10:32;2003
157. Sutton JM, Cole LA. Sialic acid-deficient invasive trophoblast antigen (sd-ITA): a new urinary variant for gestational Down syndrome screening. Prenat Diagn. 2004; 24: 194-197
158. Yarram SJ, Jenkins J, Cole LA, Tasman C, Brown N, Sandy JR, and Mansell JP. Epidermal growth factor contamination and concentrations of intact human chorionic gonadotropin in commercial preparations.
Fertil Steril 2004; 82:232-233.
159. Cole LA, Khanlian SA. Easy Fix for Clinical Laboratories for the false positive defect with the Abbott AxSym total ß-hCG test. Clin Biochem, 2004; 37:344-349.
160.  Cole LA ,Sutton JM, Higgins TN. Higgins, Cembrowski GS. Between-Method Variation in hCG Test Results, Clin Chem, 50:874-882, 2004.
161. Cole LA, Sutton JM. Selecting an Appropriate hCG Test for Management of Gestational Trophoblastic Diseases and Cancer Cases, J Reprod Med 51:217, 2006;51:217.
162. Davies S, Byrn F, Cole L.A. Testing for early pregnancy viability and complications. Clinics Lab Med, 23:257-264, 2003.
163. Butler S, Cole LA Early embryo production of hCGß and hyperglycosylated hCG. J Endocrinol 181:1209-16, 2004
165. Cole LA, Khanlian SA Response to rebuttal by Abbott Laboratories, Clin Biochem, 37: 501-502, 2004
166. Cole LA, Response to rebuttal by Inverness Medical Innovations, Am J Obstet Gynecol, in press, 2004
167. Smith HO, Qualls CR, Hilgers RD, Vershraegen CF, Rayburn WF, Cole LA, Padilla LA, Key CR. Gestational trophoblastic neoplasia in American Indians. J Reprod Med 49:535-544, 2004.
168. Cole LA, Sutton JM: Selecting an Appropriate hCG Test for Management of Gestational Trophoblastic Diseases and Cancer Cases. J Reprod Med, 49:545-553 2004.
169. Yarram SJ, Jenkins J, Cole LA, Brown NL, Sandy JR, Mansell JP. Epidermal growth factor contamination and concentrations of intact human chorionic gonadotropin in commercial preparations. Fertil Steril. 2004;82:232-3.
170. Pandian R, Cole LA, Palomaki GE. Second-trimester maternal serum invasive trophoblast antigen: a marker for Down syndrome screening. Clin Chem 2004; 50:1433-5.
171. Cole LA, Sutton-Riley JM, Khanlian SA, Borkovskaya M, Rayburn BR, Rayburn WF. Sensitivity of Over-the-Counter Pregnancy Tests: Comparison of utility and marketing messages. J Am Pharm Assoc 2005; 45:608-615.
172. Cole LA. Background hCG in healthy non-pregnant women, Clin Chem 2005; 51:1765-66.
173. Cole LA, Kohorn E, Smith HO. Gestational trophoblastic diseases: Management of cases with persistent low human chorionic gonadotropin results. Obstet Gynecol Clin N Am 2005: 32; 615-626.
174. Knight AK, Bingemann T, Cole L, Cunningham-Rundles C. Frequent false positive beta human chorionic gonadotropin in immunoglobulin A deficiency. Clin Exper Immunol 2005;141:333-337.
175. Smith HO. Kohorn E. Cole LA. Choriocarcinoma and gestational trophoblastic disease. Obstet Gynecol Clin N Amer 2005;32:661-84.
176. Knight GJ. Palomaki GE. Klee GG. Schreiber WE. Cole LA. A comparison of human chorionic gonadotropin- related components in fresh frozen serum with the proficiency testing material used by the College of American Pathologists. Arch Path Lab Med 2005;129:328-30.
177. Cole LA, Dai D, Leslie KK, Butler SA, Kohorn EI. Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG-regulated neoplasia. Gynecologic Oncology, 2006;102:144-149
178. HYPERLINK “file:///D:\\DATA\\Websites\\hcglab\\html\\MM05%20GynOnc-2.pdf” Cole LA. Butler SA. Khanlian SA. Giddings A. Muller CY. Seckl MJ. Kohorn EI. Gestational trophoblastic diseases: HYPERLINK “file:///D:\\DATA\\Websites\\hcglab\\html\\MM05%20GynOnc-2.pdf” 2. Hyperglycosylated hCG as a Reliable Marker of Active Neoplasia. Gynecologic Oncology 2006;102:150-158.
179. HYPERLINK “file:///D:\\DATA\\Websites\\hcglab\\html\\MM05%20GynOnc-3.pdf” Cole LA, Khanlian SA, Muller CY, Giddings A, Kohorn EI, Berkowitz R. Gestational trophoblastic diseases: 3 HYPERLINK “file:///D:\\DATA\\Websites\\hcglab\\html\\MM05%20GynOnc-2.pdf” . Human Chorionic Gonadotropin Free ß-subunit a Reliable Marker of Placental Site Trophoblastic Tumors. Gyn Oncol 2006;102:159-163.
180. Cole LA, Khanlian SA, Giddings A, Butler SA, Muller CY, Hammond C, Kohorn EI. Gestational trophoblastic diseases: 4. Presentation with Persistent Low Positive Human Chorionic Gonadotropin Gynecologic Oncology 2006;102:164-171.
181. Slone SP, Ahmed Z, Cole LA, Elin RJ, Martin AW, Herzig RH, Herzig GP, Miller JJ. Positive pregnancy tests in a nongravid, premenopausal woman due to hCG beta-chain production by multiple myeloma. Am J Clin Path 2005;124:108-12.
182. Khanlian SA, Cole LA. Management of Gestational Trophoblastic Diseases and Other Cases with Low Serum Levels of Human Chorionic Gonadotropin. J Reprod Med, 2006;51:812-818.
183. Cole LA, Dai D, Leslie KK, Butler SA, Kohorn EI. Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG-regulated neoplasia. Gynecologic Oncology, 2006;102:144-149
184. Cole LA, Khanlian SA, Riley JM, Butler SA. Hyperglycosylated hCG (hCG-H) in Gestational Implantation, and in Choriocarcinoma and Testicular Germ Cell Malignancy Tumorigenesis. J Reprod Med, 2006;51:919-929
185. Cole LA, Kohorn EI. The Need for an hCG Assay That Appropriately Detects Trophoblastic Disease and Other hCG-Producing Cancers. J Reprod Med 2006;51:793-811.
186. Cole LA, Sutton JM. hCG tests for managing gestational trophoblastic disease. J Reprod Med 2006;50:1-17.
187. Sutton-Riley JM, Khanlian SA, Byrn FW, Cole LA. A single serum test for measuring early pregnancy outcome with high predictive value. Clin Biochem 2006; 39:682-687.
188. Sasaki S, Cole LA, Sasaki Y, Shimizu A. Persistent low levels of hCG. Jpn J Obstet Gynecol 2006;55:661-669.
189. Cole LA, Khanlian SA Inappropriate Management of Persistent Low hCG Results. J Reprod Med, 49: 423-432, 2006.
190. Cole LA, Khanlian SA. Hyperglycosylated hCG. Molec Cell Endocrinol 2007;260:228-36.
191. Cole LA, Khanlian SA, Sasaki Y, Muller CY. Normal Production of hCG in Menopause: A Medical Management Dilemma. N Eng J Med, 2007;356:1184-86
192. Sasaki Y, Ladner DG, Cole LA Hyperglycosylated hCG the source of pregnancy failures,
Fertil Steril, 2008; 89:1871-1786.
193. Cole LA, Hyperglycosylated hCG, Placenta, 2007; 28:977-986.
194. Cole LA, Khanlian SA, Muller CY. Blood Test for Placental Site Trophoblastic Tumor (PSTT) and for Non-Trophoblastic Malignancy for Evaluating Patients with Low Positive hCG Results. J Reprod Med 2008;53:457-464.
195. Cole LA, Butler SA, Hyperglycosylated hCG and its Free ß-subunit, Tumor Markers and Tumor Promoters: A Review. J Reprod Med 2008;53:499-510.
196. Cole LA, Khanlian SA, Muller CW, Detection of hCG Peri- or Post-Menopause an Unnecessary Source of Alarm. Am J Obstet Gynecol 2008;198:275-279
197. Cole LA, Khanlian SA, Kohorn EI, Evolution of the Human Brain, Chorionic Gonadotropin and Hemochorial Implantation of the Placenta: Origins of Pregnancy Failures, Preeclampsia and Choriocarcinoma. J Reprod Med 2008; 53:449-557.
198. Badgwell D, Lu Z, Cole LA, Fritsche H, Atkinson EN, Somers E, Allard J, Moore RG, Lu KH, Bast RC. Urinary mesothelin provides greater sensitivity for early stage ovarian cancer than serum mesothelin, urinary hCG free beta subunit and urinary hCG beta core fragment. Gyn Oncol 2007; 106:490-497.
199. Cole LA, Khanlian SA, Muller C. Normal Production of Human Chorionic Gonadotropin in Perimenopausal and Menopausal Women and following Oophorectomy, Intl J Gyn Cancer 2009; 19:1556-1559.
200., Muller C, Cole LA. The Quagmire of hCG and hCG Testing in Gynecologic Oncology
Gynecol Oncol, 2009; 112:663-672.
201. Cole LA, Ladner DG. Background hCG in Non-Pregnant Individuals: Need for More Sensitive Point-of-Care and Over-the-Counter Pregnancy Tests, Clin Biochem, 2009; 42:168-175.
202. Cole LA, New Discoveries on the Biology and detection of hCG, Reprod Biol Endocrinol, 2009;7;1-37.
203. Cole LA, Human Chorionic Gonadotropin and Associated Molecules. Expert Rev Molec Diag, 2009; 9:51-73.
204. Cole LA, Khanlian SA, The need for a quantitative urine hCG assay. Clin Biochem, 2009. 42:676-683.
205. Cole LA, Ladner DG, Byrn FW. The Normal Variabilities of the Menstrual Cycle
and the Menstrual Cycle Leading to Pregnancy. Fertil Steril; 2009; 91:522-527.
206. Cole LA, hCG and hyperglycosylated hCG in the establishment and evolution of hemochorial placentation. J Reprod Immunol 2009;82:111-117.
207. Cole LA, Muller CY. New Approach to Treating Gestational Trophoblastic Neoplasms. J Reprod Med, in press 2009.
208. Cole LA. hCG Tests. Expert Rev Molec Diag, 2009; 9:721-749.
209. Cole LA, Muller Y. hCG in the Management of Quiescent and Chemorefractory Gestational Trophoblastic Diseases, Gynecol Oncol 2010;116:3-9.
210. Cole LA. Chapter 38: hCG and the future. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 381-382.
211. Cole LA. Chapter 2: History and introduction to human chorionic gonadotropin (hCG): One name for at least three independent molecules. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 13-22.
212. Cole LA. Chapter 3: Introduction to pregnancy implantation, villous formation, and hemochorial placentation In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 23-34.
213. Cole LA, Butler SA. Chapter 5: Structure, synthesis, secretion, and function of hCG. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 49-65.
214. Cole LA. Chapter 6: Comparison of structures of hCG and hyperglycosylated hCG. 
In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 67-78.
215. Cole LA. Chapter 7: Structures of free α-subunit and free ß-subunit In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 79-86.
216. Cole LA. Chapter 9: Degradation products of hCG, hyperglycosylated hCG, and free ß-subunit. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 113-122.
217. Cole LA. Chapter 10: The three dimensional structure of hCG. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 123-128.
218. Cole LA, Butler SA. Ch 12: The hCG receptor. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 139-144.
219. Cole LA. Chapter 13: Biological functions of hyperglycosylated hCG In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 145-152.
220. Cole LA. Chapter 17: Illicit use of hCG in dietary programs and use to promote anabolism. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 213-21221. Cole LA. Chapter 18: Antibodys for intact hCG, total hCG, free subunits, glycosylation variants, and hCG fragments. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 221-226.
222. Cole LA. Chapter 19: Quantitative hCG assays. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 227-232.
223. Cole LA. Chapter 20: false-positive hCG assays. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 233-340.
224. Cole LA. Ch 21: specificity of different hCG assays. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 241-250.
225. Cole LA. Ch 22: point-of-care pregnancy tests. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 251-254.
226. Cole LA. Chapter 23: Over-the-counter pregnancy tests. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 255-262.
227. Cole LA. Chapter 25: Background hCG. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 275-284.
228. Cole LA. Chapter 26: Pregnancy testing. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 285-290.
229. Cole LA. Chapter 27: Predicting spontaneously aborted (SAB) pregnancies. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 291-298.
230. Cole LA. Chapter 28: hCG, hyperglycosylated hCG, and free ß-subunit in predicting Down syndrome pregnancies and preeclampsia. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 299-304.
231. Cole LA. Chapter 29: hCG in monitoring gestational trophoblastic diseases. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 305-310.
232. Cole LA, Muller CY. Chapter 30: Use of hyperglycosylated hCG as a unique marker of gestational trophoblastic neoplasms. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 311-326.
233. Cole LA. Ch 31: Pituitary hCG and familial hCG. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 329-342,
234. Cole LA. Chapter 32: hCG, free ß-subunit and ß-core fragment as markers of malignancies. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 343-348.
235. Cole LA. Chapter 33: hCG and hyperglycosylated hCG purification from serum, urine, and culture fluids. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 351-354.
236. Cole LA. Chapter 34: Dissociation, desialylation, and cleavage of hCG. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 355-356.
237. Cole LA. Chapter 35: hCG and free ß-subunit producing cell lines. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 357-360.
238. Cole LA. Chapter 36: Evolution of hCG, evolution of humans, evolution of human pregnancy disorders and cancer. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 363-376
239. Cole LA. Ch 37: hCG a remarkable molecule. In: Human chorionic gonadotropin (hCG). Ed. Cole LA, Elsevier, Burlington MA, 2010, pp 377-380
240. Cole LA. Chapter 1: The gonadotropins. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
241. Cole LA. Chapter 2: Gonadotropin releasing hormone (GnRH), the hypothalamic-pituitary-gonad axis. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.242. Cole LA. Chapter 3: Estrogens and progestagens. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
243. Cole LA. Chapter 4: Follicular growth and selection, preparation for ovulation, ovulation and luteinization. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
244. Cole LA. Chapter 5: Putting everything together: The menstrual cycle. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
245. Cole LA. Chapter 6: Ovarian cystic disorders. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
246. Cole LA. Chapter 7: Contraception. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
247. Cole LA. Chapter 8: Male steroidogenesis. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
248. Cole LA. Chapter 9: Sperm production and seminal fluids. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
249. Cole LA. Chapter 10: Erection and ejaculation. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
250. Cole LA. Chapter 11: Sex and Science. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
251. Cole LA. Chapter 12: Fertility and Infertility. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
252. Cole LA. Chapter 13: Coitus, fertilization and blastocyst formation. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
253. Cole LA. Ch 14: hCG and hyperglycosylated hCG. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elsevier, Burlington MA, 2011, in press.
254. Cole LA. Chapter 15: The placenta, hemochorial placentation, and implantation. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
255. Cole LA. Chapter 16: Human placental lactogen, human placental growth hormone and sex steroid function in pregnancy. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
256. Cole LA. Chapter 17: Fetal growth, gender and gonadal development. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
257. Cole LA. Chapter 18: Parturition. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
258. Cole LA. Chapter 19: Placentation disorders and failures of early pregnancy. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
259. Cole LA. Chapter 20: Perinatal complications of pregnancy. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
260. Cole LA. Chapter 21: Mammary gland and Breast Feeding. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
261. Cole LA. Chapter 22: Adrenarche and menarche in girls. In: Fundamentals of reproductive
medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
262. Cole LA. Chapter 23: Adrenarche in boys. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elsevier, Burlington MA, 2011, in press.
263. Cole LA. Chapter 24: Physiology of peri-menopause and menopause. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
264. Cole LA. Chapter 25: Coping with menopause. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
265. Cole LA. Chapter 26: Pelvic inflammatory disease and infections of the reproductive tract. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
266. Cole LA. Chapter 27: Endometriosis. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
267. Cole LA. Chapter 28: Sexually transmitted diseases. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
268. Cole LA. Chapter 29: Hormones, familial factors and breast cancer. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
269. Cole LA. Chapter 30: Cervical, ovarian and endometrial neoplasms. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
270. Cole LA. Chapter 31: Hormone and gestational trophoblastic neoplasms. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
271. Cole LA. Chapter 32: Hormones and testicular and prostate malignancies. In: Fundamentals of reproductive medicine. Ed. Cole LA, Elesevier, Burlington MA, 2011, in press.
272. Cole LA, Gutierrez JM. Production of hCG during the menstrual cycle. J Reprod Med 2009; 54:245-250.
273. Cole LA, Laidler LL. Inherited hCG, J Reprod Med, 2010;55:99-102.
274. Cole LA. Biological Functions of hCG and hCG-Related Molecules, Reprod Biol Endocrinol, 2010;8:102-116.
275. Cole LA, Laidler L, Muller C. USA hCG Reference Service, 10 year report, Clin Biochem, 2010; 43:1013-1022.
276. Cole LA, Hyperglycosylated hCG, A Review, Placenta, 2010; 8: 853-664.
277. Cole LA, The USA hCG Reference Service: What we investigate, how we examine blood and urine samples, and what we find? http://www.hcglab.com.
278. Cole LA, Hyperglycosylated hCG , the most valuable test in the management of gestational trophoblastic neoplasms.Troph Dis Upd 10: 5-22, 2010.
279. Cole LA, The untility of 6 over-the-counter (home) pregnancy tests. Clin Chem Lab Med. 2011; 49:1317-1322.
280. Cole LA, Individual Deviations in hCG Concentrations During Pregnancy, Am J Ostet Gynecol 2011; 204:359-351.
281. Cole LA. Human chorionic gonadotropin and hyperglycosylated human chorionic gonadotropin the mediator which control human pregnancy. Exp Rev Obstet Gynecol 2011;6:273-283.
282. Butler SA, Kaluarachchi M, Lutoo J, Cole LA, IIes RK. Analysis of hCGßcf glycosylation in normal and abherrant pregnancy by matrix-assisted laser desorption/ionization time of flight mass spectrometry. Int J Mol Sci 2014; 15:10067-10082.
283. Nimi K, Yamamoto E, Ino K, Cole LA, Fujiwara S, Shibata K, Kikkawa H.
N-acetylglucosaminyltransferase IVa regulates invasiveness of choriocarcinoma cells. Endocrinol 2013, in press.
284. Cole LA. Familial hCG. J Reprod Immunol 2012,93:52-57.
285. Cole LA, Butler SA. Hyperglycosylated hCG, hCGß and Hyperglycosylated hCGß: Interchangeable Cancer Promoters. Molec Cellul Endcrinol 2012;349:232-238.
286. Cole LA. hCG, Five Independent Molecules. Clin Chim Acta 2012, 413:48-65.
287. Cole LA, DuToit S, Higgins TN. Total hCG tests. Clin Chim Acta 2011; 412:2216-2222.
288. Cole LA. hCG Variants, the Growth Factors Which Drive Human Malignancies. Am J Cancer Res 2011,2:22-35.
289. Cole LA. The hCG assay or Pregnancy Test. Clin Chem Lab Med 2012, 49:617-630.
290. Cole LA. Human chorionic gonadotropin (hCG) and hyperglycosylated hCG – the mediators that control human pregnancy. Expert Rev Obstet Gynecol 2011;6:273-283.
291. Cole LA. hCG and Hyperglycosylated hCG, Promoters of Villous Placenta and Hemochorial Placentation. Placenta: Functions, Development and Disease, Nova Publishers, 2013, in press.
292. Cole LA. Minimally-Aggressive Gestational Trophoblastic Neoplasms. Gynecol Oncol 2012; 126: 145-150.
293. Cole LA. hCG the centerpiece of life and death. Intl J Endocrinol Metab 2011;9:225-242.
294. Cole LA, Butler SA. Hyperglycosylated hCG and hCG Free ß-Subunit, Hyperglycosylated hCG and its ß-Subunit: Pervasive Promoters of Invasion and Growth in Cancer. Molec Cellul Endocrinol 2013; in press.
295. Cole LA. hCG Structure: A Logical Perspective. Asian Pacific J Reprod 2012; 1:287-292.
296. Cole LA. hCG, the wonder of today’s science. Reprod Biol Endocrinol 2012; 10:1-18.
297. Cole LA, Butler SA. Familial hCG Syndrome: Production of Mutant Forms of hCG. J Reprod Immunol 2013; in press.
298. Cole LA, Butler SA. Hyperglycosylated hCG, hCGß and Hyperglycosylated hCGß: Interchangeable Cancer Promoters. Molec Cellul Endocrinol 2012, 349, 232-238.
299. Cole LA. Human chorionic gonadotropin (hCG), a peculiarity of biochemistry. Arch Biochem Biophys 2013; in press.
300. Cole LA. Hyperglycosylated hCG and Pregnancy Failures. J Reprod Immunol 2012;93:119-122.
301. Cole LA, Butler SA. The biological function of hyperglycosylated hCG. Asian Pacific J Reprod 2013:1;7-12. 
302. Brennan MC, Wolfe MD, Murray-Krezan CM, Cole LA, Rayburn WF. First Trimester Hyperglycosylated Human Chorionic Gonadotropin and Development of Hypertension. Prenat Diagn 2013; 33: 1075-1079.
303. Iles RK, Malatos S, Cole L.A., Butler S. Direct analysis of hCGβcf glycosylation in normal and aberrant 
pregnancy by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Mass Spectrom Appl Biol, 2014, in press.
304. Cole LA, Butler SA. B152 Anti-Hyperglycosylated hCG free β-Subunit A New Possible Treatment For Cancer. J Reprod Med, 2014, in press.